New Historicist critics have a certain fondness for comparative analyses of scientific and aesthetic texts, although the complex theoretical premises of this approach have rarely been discussed. This essay proposes an interdisciplinary approach which—in contrast to the New Historicist approach—accounts for discursive difference, i.e., achieves a correlation of different discursive fields without simply equating them. This approach consists of a combination of the epistemological and the hermeneutic method, since only by way of the critic’s awareness of universality and specificity, of interdiscursive conditions and discursive peculiarities, is his or her desire for absolute and universal knowledge to be contained.