Despite their prominent, and ongoing, significance within cinematic production and reception, serial narratives have been curiously neglected within film scholarship. This special issue of Film Studies examines diverse forms, processes, and contexts of film seriality from the 1910s to the contemporary period, outlining various approaches to a topic that is integral to cinema and other popular media. Taking inspiration from the interdisciplinary initiative of seriality studies, the articles presented here explore cinema’s medium-specific serial forms and the manner in which its serial enterprises have been shaped by developments elsewhere in popular culture.